Hantzsch ester → HCID 22617822, compound

Participants

Reaction Steps

To oven-dried SiO2(150 mg) in toluene (2 mL) was added 50 mg of the thiazolidinylidene olefin (Example 1) with diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (25 mg). The mixture was stirred and heated at 70-90° for 3 days. Mass spectral monitoring indicated the reaction was complete. Silica was filtered and washed with EtOAc and combined volatiles were removed under reduced pressure to a residue. The solid dissolved in ether and solids were filtered and discarded. Ether was evaporated and residue was washed with hexanes and air-dried to afford the reduction product; ms: m/e 512 (M+1); HPLC ˜70% pure.

Provenance & Evidence