1-Benzylpiperidin-3-amine → (2S)-1-(1,3-benzoxazol-2-yl)-N2-(1-benzyl-3-piperidinyl)hexahydro-2-pyridinecarboxamide

Participants

Reaction Steps

The title compound was prepared by a similar method to Example 1 from (2S)-1-(1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid [see Preparation 3] and 1-benzyl-3-piperidinylamine [see J. Med. Chem. (1980), 23(8), 848-851]. The crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 90:10 changing to 40:60, by volume, hexane:ethyl acetate in 10% increments, to afford (2S)-1-(1,3-benzoxazol-2-yl)-N2-(1-benzyl-3-piperidinyl)hexahydro-2-pyridinecarboxamide as a yellow gum.

Provenance & Evidence