HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-1-(3-pyridinylmethyl)pyrrolidine-3-amine → (2S)-1-(1,3-benzothiazol-2-yl)-N-[(3S)-1-(3-pyridinylmethyl)pyrrolidin-3-yl]-2-piperidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-1-(3-pyridinylmethyl)pyrrolidine-3-amine | HCID 28360955 | — |
| Reactant | (2S)-1-(1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid | HCID 30121374 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | (2S)-1-(1,3-benzothiazol-2-yl)-N-[(3S)-1-(3-pyridinylmethyl)pyrrolidin-3-yl]-2-piperidinecarboxamide | HCID 57126240 | — |
Reaction Steps
The title compound was prepared by a similar method to Example 1, excepting that a catalytic amount of 4-dimethylaminopyridine was also used, from (2S)-1-(1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid [see Preparation 43] and (3S)-1-(3-pyridinylmethyl)pyrrolidine-3-amine [see Preparation 41] to afford (2S)-1-(1,3-benzothiazol-2-yl)-N-[(3S)-1-(3-pyridinylmethyl)pyrrolidin-3-yl]-2-piperidinecarboxamide as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372736B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-aa8c84558022401e943733d9ebd643de |
| Source note | uspto-grants-2002_04 |