HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → (2S)-1-(1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | ethyl (2S)-1-(1,3-benzothiazol-2-yl)-2-piperidinecarboxylate | HCID 57016205 | — |
| Product | (2S)-1-(1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid | HCID 30121374 | — |
Reaction Steps
The title compound was prepared by a similar method to Preparation 3 from ethyl (2S)-1-(1,3-benzothiazol-2-yl)-2-piperidinecarboxylate [see Preparation 42] and 1N aqueous lithium hydroxide solution. The crude product was purified by column chromatography on silica gel eluting with a solvent system of 10:1, by volume, dichloromethane: methanol to afford (2S)-1-(1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372736B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-e626b8ba7fd54e1aa09f70e40652b5ef |
| Source note | uspto-grants-2002_04 |