HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | 4-(2-Bromoethoxy)Benzaldehyde | HCID 262706 | — |
| Reactant | 2-Ethyl-6-methylpyrimidin-4(1h)-one | HCID 135417368 | — |
| Product | 4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]benzaldehyde | HCID 11748147 | 42% |
Reaction Steps
The title compound (1.7 g, 42%) was prepared from 2-ethyl-4-methyl-1,6-dihydro-6-pyrimidone (2.0 g, 14.49 mmol), 4-[2-bromoethoxy]benzaldehyde (3.32 g, 14.49 mmol), LiBr (2.9 g 33.33 mmol) and NaH (0.45 g, 18.84 mmol) as base, by a similar procedure to that described in preparation 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372750B2 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-97a83470651a4c15bba93e3297900332 |
| Source note | uspto-grants-2002_04 |