Hydroxyamine hydrochloride → HCID 18406979, compound

Participants

Reaction Steps

Dissolve (3E)-3-(2,4-dimethoxyphenyl)-4-(dimethylamino)but-3-en-2-one (5.1 g, 20.6 mmol) in EtOH (50 mL) and add NH2OH.HCl (3.05 g, 44.0 mmol). Heat to reflux under N2 for 20 minutes. Cool and evaporate to red-brown oil. Dissolve in CH2Cl2, dry over Na2SO4, filter and concentrate to red-brown oil (4.4 g). Use without further purification. LCMS=220.2 (MH+); 218.2 (M−).

Provenance & Evidence