Acetic Acid → HCID 178476650, compound

HRID 842017Notes

Reaction equation

HRID 842017 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH3:16])=[CH:10][C:9]=1[CH3:17].C(O[C:21](=[NH:23])[CH3:22])C.[C:24]([OH:27])(=[O:26])[CH3:25]>C(#N)C>[C:24]([OH:27])(=[O:26])[CH3:25].[NH:23]=[CH:21][CH2:22][NH:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH3:16])=[CH:10][C:9]=1[CH3:17]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 65066Ethyl acetimidateHCID 178489813HCID 178489813, compound

Product 1

HCID 178476650HCID 178476650, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 5-amino-4-(4-methoxy-2,6-dimethylphenyl)-3-methylpyrazole (1.89 g) (prepared from 4-methoxy-2,6-dimethyl benzaldehyde according to Example 1 C-F) in acetonitrile (30 mL) add ethylacetimidate (free base, 1.8 mL) followed by acetic acid (0.47 mL). Collect the precipitate that formed upon stirring overnight by filtration. Wash the solid with dry ether and dry to afford 2.61 g of (iminoethyl)[4-(4-methoxy-2,6-dimethylphenyl)-3-methylpyrazol−5-yl]amine acetate salt as a white powder.

Workup

  1. customCollect the precipitate
  2. customthat formed
  3. washWash the solid with dry ether
  4. customdry

Sources & evidence

ORD record
ord-b4946de161d4494a952c848dfe129f20
Source dataset
uspto-grants-2002_04
Patent number
US06372743B1

Reaction notes

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