Methyl acetoacetate → HCID 178491887, compound

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Reaction Steps

To a solution of 4-(2,6-dichloro-4-methoxy-phenyl)-5-methyl-2H-pyrazol-3-ylamine (10.1 g, 39 mmol) in acetic acid (17 mL) was added methyl acetoacetate. After the mixture was heated at reflux for 3 hours it was cooled and then diluted with diethyl ether (50 mL) to generate a colorless precipitate. The solid was collected by vacuum filtration and washed with additional ether to afford the title compound as a colorless solid (10.3 g, 77%): +APcI MS (M+1)+338; 1H NMR (methanol-d4) δ: 7.14 (s, 2H), 5.68 (s, 1H), 3.86 (s, 3H), 2.30 (s, 3H), 2.16 (s, 3H).

Provenance & Evidence