Water → 2-Bromo-4-(trifluoromethoxy)phenol

Temperature

0 °C

To a cooled (0° C.) solution of 4-(trifluoromethoxy)phenol (35.6 g, 0.2 mol) in chloroform (280 ml) was added dropwise a solution of bromine (32 g, 0.2 mol) in chloroform (50 ml). The solution was stirred at 0° C. for 1 hour and at room temperature for 2 hours. Dichloromethane (200 ml) and water (400 ml) were added and the organic phase was washed further with water (400 ml), brine (200 ml) and dried (MgSO4). The solvent was removed and the residue was purified by distillation at reduced pressure to give the title compound. 1H NMR (250 MHz, CDCl3) δ 7.38 (1H, d, J 2.1 Hz), 7.13 (1H, dd, J 9.1, 2.1 Hz), 7.03 (1H, d, J 9.1 Hz), 5.53 (1H, s).

1. washthe organic phase was washed further with water (400 ml), brine (200 ml)
2. dry with materialdried (MgSO4)
3. customThe solvent was removed
4. distillationthe residue was purified by distillation at reduced pressure

ORD record

ord-287628c96cc7417aa887dfd7db3e29ac

Source dataset

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06372754B1