HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 842056Generated: October 31, 2026
Sodium Hydroxide → Ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate
https://huagongshe.com/reaction/842056
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate | HCID 657593 | — |
| Product | Ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate | HCID 239537 | 85.2% |
Reaction Steps
A mixture of ethyl 3,4-dihydro-4-oxo-2-phenylpyrimidine-5-carboxylate (12 g) and phosphorus oxychloride (22.6 g) is stirred at 90° C. for four hours. The reaction mixture is poured into ice-water, and the mixture is neutralized with 1N aqueous sodium hydroxide solution. The precipitates are collected by filtration, and washed with water to give the desired compound (11 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06372740B1 |
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| Source dataset | uspto-grants-2002_04 |
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| ORD ID | ord-23bc35c148d94127b95f433afbde5c26 |
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| Source note | uspto-grants-2002_04 |
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