Glycine → HCID 22617810, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate (21 g), glycine (6.6 g), trimethylamine (17.8 g) and ethanol (200 ml) is refluxed for four hours. The reaction mixture is concentrated under reduced pressure, and the residue is dissolved in water. To the mixture is added dropwise conc. hydrochloric acid under stirring at 0-5° C. until the value of the mixture is adjusted to pH 4. The precipitates are collected by filtration, and washed with water to give crude N-(5-ethoxycarbonyl-2-phenyl-4-pyrimidinyl)glycine (24 g).

Provenance & Evidence