Dimethylformamide → HCID 15462527, compound

Participants

Reaction Steps

A mixture of 7,9-dihydro-9-methyl-2-phenyl-8H-purin-8-one (22.6 g), ethyl chloroacetate (13.5 g), potassium carbonate (15.2 g) and dimethylformamide (250 ml) is stirred at room temperature for one hour. To the reaction mixture are added water and chloroform, and the chloroform layer is separated, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give crude ethyl 8,9-dihydro-9-methyl-8-oxo-2-phenyl-7H-purin-7-acetate (26 g).

Provenance & Evidence