HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → HCID 15462531, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 15462528 | HCID 15462528 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 15462531 | HCID 15462531 | 92.3% |
Reaction Steps
A mixture of 8,9-dihydro-9-methyl-8-oxo-2-phenyl-7H-purin-7-acetic acid (3 g) obtained in Example 48-(2), aniline (1.3 g), BOP reagent (5.1 g), triethylamine (1.2 g) and dimethylformamide (20 ml) is stirred at room temperature for two hours. To the reaction mixture is added water, and the precipitates are collected by filtration, and washed with water to give crude 8,9-dihydro-9-methyl-8-oxo-2-phenyl-N-phenyl-7H-purin-7-acetamide (3.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372740B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-7a07851d59c848abacecea39377dd8c4 |
| Source note | uspto-grants-2002_04 |