Ethanol → HCID 9952217, compound

Participants

Reaction Steps

A mixture of 2-[2-(4-chlorophenyl)-5-nitro-4-pyrimidinylamino]-N,N-dipropylacetamide (9 g), platinum (IV) oxide (1 g) and ethanol (150 ml) is stirred under hydrogen atmosphere for four hours, and the reaction mixture is filtered. The filtrate is concentrated under reduced pressure, and to the resulting residue is added urea (2.1 g). The mixture is stirred at 200° C. for two hours. After cooling, water is added to the reaction mixture, and the precipitates are collected by filtration, washed with water, and recrystallized from ethanol to give the desired compound (7 g).

Provenance & Evidence