HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-chloro-6-nitrophenol → 2-Amino-6-bromo-4-chlorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-chloro-6-nitrophenol | HCID 291871 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Amino-6-bromo-4-chlorophenol | HCID 15521089 | 99% |
Reaction Steps
A solution of 2-bromo-4-chloro-6-nitro-phenol (16.27 g, 64.4mmol) in ethyl acetate (160 ml) was hydrogenated, at room temperature, with Raney-nickel (6 g). After hydrogen uptake (approx. 4.8 l) was complete, the nickel was removed by filtration and the filtrate evaporated in-vacuo to give 14.19 g (99.0%) of the title compound which was suitable for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372770B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-9089cdaa3a2f4f20a02d3ec127646d4e |
| Source note | uspto-grants-2002_04 |