1H-imidazole-2-carbaldehyde → HCID 54223994, compound

Participants

Reaction Steps

By employing a procedure similar to that in Example 33 and using 2-(3-cyclopentyloxy-4-methoxybenzyl)-7-aminobenzoxazole (1.3 g, 0.0038 mol), imidazole-2-carboxaldehyde (0.54 g, 0.0056 mol) and sodium cyanoborohydride (0.38 g, 0.0060 mol), a yellow oil was obtained after workup. The oil was triturated with a 50:50 blend of hexane in ether and the solid product (0.5 g) which was obtained, was separated by filtration. This solid could be recrystallized from ethanol (1 g/14 ml) to give the title compound as white crystals, mp 179-180° C.

Provenance & Evidence