HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorophenylacetic acid → N-(3-chlorophenylacetyl)-2-hydroxy-3-bromo-5-chloroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorophenylacetic acid | HCID 15879 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2-Amino-6-bromo-4-chlorophenol | HCID 15521089 | — |
| Product | N-(3-chlorophenylacetyl)-2-hydroxy-3-bromo-5-chloroaniline | HCID 22618247 | 67.5% |
Reaction Steps
Using the normal amide forming conditions, the condensation of 3-chlorophenylacetic acid (13.54 g, 0.079 mol) and 2-hydroxy-3-bromo-5-chloroaniline (17.7 g, 0.079 mol) with 1,1′-carbonyl diimidazole (13.5 g, 0.083 mol) gave the title compound (20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372770B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-8cb384c7dedf4082999b9fd54f8ca7c8 |
| Source note | uspto-grants-2002_04 |