p-Toluenesulfonic acid monohydrate → HCID 22618276, compound

Participants

Reaction Steps

N-[3-(3,4-dimethoxyphenyl)propanoyl-2-hydroxy-5-chloro-aniline (2.3 g, 6.3 mmol) in toluene (30 ml) and p-toluenesulfonic acid monohydrate (0.3 g, 1.5 mmol) was heated under reflux for 3 hours. The cooled reaction mixture was decanted from some tar and the toluene was evaporated. The residue was crystallized from t-butyl methyl ether with charcoal to give 1.3 g of the title compound which was recrystallized from t-butyl methyl ether to give pure title compound (1.08 g) mp 102-105° C.

Provenance & Evidence