5-Chloro-2-(2-chlorophenyl)-7-(3-hydroxy-1-propynyl)-benzoxazole → 5-Chloro-2-(2-chlorophenyl)-7-(3-hydroxy-propyl)-benzoxazole

Participants

Reaction Steps

A suspension of 11.07 g (34.8 mmol) of 5-chloro-2-(2-chlorophenyl)-7-(3-hydroxy-1-propynyl)-benzoxazole in 120 ml of ethyl acetate was treated with 3.70 g of neutral Raney-nickel. After the hydrogen uptake ceased, the nickel was filtered off and washed, and the solution evaporated in vacuo. Crystallization from dichloromethane/di-isopropyl ether gave the title compound in two crops (6.12 g (54.6%) and 1.61 g (14.4%)), mp 82-4° C.

Provenance & Evidence