Ammonia → HCID 22618325, compound

Participants

Reaction Steps

1.00 g (1.6 mmol) of 5-chloro-2-(3-cyclopentyloxy-4-methoxy-phenyl)-7-[3-(N-t-butyloxycarbonyl-N-t-butoxycarbonyloxy-amino)-1-propynyl]-benzoxazole was dissolved in 20 ml of THF and treated with 20 g of ammonia in a reactor. The pressure rose to 100 psi. After 2 hours, the solvents were removed in vacuo. Crystallization from methanol and recrystallization from di-isopropyl ether gave the title compound (0.47 g, 56.2%), mp 157-61° C.

Provenance & Evidence