HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 1-(3-Chlorophenyl)-5-methyl-2-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-Chloroaniline | HCID 7932 | — |
| Reactant | Ethyl 2-benzoyl-4-oxopentanoate | HCID 14689358 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3-Chlorophenyl)-5-methyl-2-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester | HCID 10268802 | — |
Reaction Steps
m-Chloroaniline (5 mmol, 0.6 g), 2-benzoyl-4-oxo-pentanoic acid ethyl ester (5 mmol, 12 g), and tosic acid (0.1 g) were combined in ethanol, then heated under reflux. Upon completion of the reaction, the crude solid was recrystallized from ethanol to provide the named product (m.p. 93.2° C.-94.6° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372777B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-264705fab0b941208e76ea462d003d33 |
| Source note | uspto-grants-2002_04 |