HCID 9924533, compound → HCID 9944931, compound

HRID 842208Notes

Reaction equation

HRID 842208 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)[C:7]=1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:5])[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[C:7]=1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 9924533HCID 9924533, compound

Product 1

HCID 9944931HCID 9944931, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

5-Methyl-1-(4-nitrophenyl)-2-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester of Example 36 (4 mmol, 1.5 g) was dissolved in ethanol, and treated with 5% Pd/C (0.15 g). The mixture was hydrogenated with H2(g) at 45 psi. Upon completion of the reaction, the mixture was filtered through Celite, and the solvents removed under vacuum. Analysis of the resulting solid showed it was the named product (m.p. 181° C.-183° C.)

Workup

  1. customUpon completion of the reaction
  2. filtrationthe mixture was filtered through Celite
  3. customthe solvents removed under vacuum

Sources & evidence

ORD record
ord-6193ec8c3b364d4daec74ed4e4feb759
Source dataset
uspto-grants-2002_04
Patent number
US06372777B1

Reaction notes

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