Sodium borohydride → HCID 491837, compound

HRID 842210Notes

Reaction equation

HRID 842210 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-])=O)[CH:18]=2)[C:7]=1[CH3:26])=[O:5])[CH3:2].[BH4-].[Na+]>CO.Cl[Ni]Cl>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=2)[C:7]=1[CH3:26])=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 9798485HCID 9798485, compound

Product 1

HCID 491837HCID 491837, compound

Reagents, catalysts & solvents 2

HCID 24385Nickel DichlorideCatalystHCID 887MethanolSolvent

Procedure

The compound of Example 22 (0.86 mmol, 0.3 g) was dissolved in methanol and treated with NiCl2 and NaBH4 (17.2 mmol) using the procedure set forth in Example 40. The named product was purified over silica (m.p. 142° C.-143° C.).

Workup

  1. customThe named product was purified over silica (m.p. 142° C.-143° C.)

Sources & evidence

ORD record
ord-a82b9bdcefbe4f74835067a51b6921ac
Source dataset
uspto-grants-2002_04
Patent number
US06372777B1

Reaction notes

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