Ethylene Glycol → HCID 70154334, compound

Participants

Reaction Steps

A solution of 0.046 g (0.104 mmol) of 1-benzyl-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(SR)-formylpyrrolidine, 0.058 mL (1.04 mmol) of ethyleneglycol and 0.047 g (0.25 mmol) of TsOH.H2O in 5 mL of benzene was heated at reflux for 2 h. The reaction mixture was cooled to rt and diluted with ether. The reaction mixture was washed twice with sat'd NaHCO3 solution, dried over Na2SO4, filtered and the filtrate was concentrated. The residue was purified by chromatography (silica, MeOH:CH2Cl2, 5:95) to give the title compound.

Provenance & Evidence