HRID842233

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18388362

1-Methyl-1H-indole-7-carboxylic acid

C10H9NO2

结构：OC(c1ccccc1)C1CNCC1CN1CCC(c2ccc(F)cc2)CC1

HCID18388375

未命名化合物

PRODUCTS

生成物

结构：Cn1ccc2cccc(C(=O)N3CC(CN4CCC(c5ccc(F)cc5)CC4)C(C(O)c4ccccc4)C3)c21

HCID18723501

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(RS)-(phenylhydroxymethyl)pyrrolidine and 1-methyl-7-indolecarboxylic acid according to procedures described in Example 39. The crude product was purified by chromatography (silica, acetone:hexane=1:2) to give the separate diastereomers of the title compound.

WORKUP

后处理

customThe crude product was purified by chromatography (silica, acetone:hexane=1:2)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4831431a93b2417a9f9000d4cb2e4411
来源数据集: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06372764B1
来源说明: uspto-grants-2002_04

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]3[CH:19]([CH:20]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[OH:21])[CH2:18][NH:17][CH2:16]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:28][N:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][C:36]=2[C:38](O)=[O:39])[CH:31]=[CH:30]1>>[CH3:28][N:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][C:36]=2[C:38]([N:17]2[CH2:18][CH:19]([CH:20]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[OH:21])[CH:15]([CH2:14][N:11]3[CH2:12][CH2:13][CH:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[CH2:9][CH2:10]3)[CH2:16]2)=[O:39])[CH:31]=[CH:30]1