Methanol → Methyl 2-amino-4-(4-octylphenyl)butyrate hydrochloride

HRID 842263Notes

Reaction equation

HRID 842263 reaction equation
[ClH:1].[NH2:2][CH:3]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][CH:10]=1)[C:4]([OH:6])=[O:5].[CH3:23]O>S(Cl)(Cl)=O>[ClH:1].[NH2:2][CH:3]([CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:13][CH:14]=1)[C:4]([O:6][CH3:23])=[O:5]

Participants

4

Reactant 2

HCID 887MethanolHCID 701487132-Amino-4-(4-octylphenyl)butanoic acid hydrochloride

Product 1

HCID 22618877Methyl 2-amino-4-(4-octylphenyl)butyrate hydrochloride

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

To a solution of 2-Amino-4-(4-octylphenyl)butanoic acid hydrochloride (20 g) in methanol (500 ml), thionyl chloride (7.2 ml) was added under ice-cooling and the mixture was left standing overnight. The reaction mixture was concentrated under reduced pressure to give the subject compound (16 g).

Workup

  1. temperaturecooling
  2. waitthe mixture was left
  3. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2ab4f55a01764609a51654ba1d4b02ca
Source dataset
uspto-grants-2002_04
Patent number
US06372800B1

Reaction notes

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