反应详情

温度

40 °C

(−) secoisolariciresinol (100 mg) was dissolved in acetonitrile (5 ml) and to it was added a solution of triphenyl phosphine bromide in acetonitrile (1 ml) and the mixture was stirred at 0-80° C. for 1-10 hours. After completion of the reaction, the reaction mixture was concentrated under vacuum and the residue thus obtained was chromatographed over silica gel column. Elution of the column with 30% EtOAC in pet. ether gave (−) 3,4-divanillyl tetrahydrofuran (78 mg), m.p. 114-116° C.

1. customAfter completion of the reaction
2. concentrationthe reaction mixture was concentrated under vacuum
3. customthe residue thus obtained
4. customwas chromatographed over silica gel column
5. washElution of the column with 30% EtOAC in pet. ether