p-Anisoyl chloride → HCID 18373183, compound

HRID 842366Notes

Reaction equation

HRID 842366 reaction equation
C([C:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18](=[O:36])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[NH:25][C:26](=[O:35])[C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=3)=[CH:14][CH:15]=2)[NH:10][N:9]=1)(OC(C)(C)C)=O.C(Cl)(=O)C1C=CC(OC)=CC=1.NC1C=CC=CC=1C(NC1C=C2C(C=NN2[C:63]([O:65][C:66]([CH3:69])([CH3:68])[CH3:67])=[O:64])=CC=1)=O>>[C:63]([N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:36])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[NH:25][C:26](=[O:35])[C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=3)[CH:12]=2)[CH:8]=[N:9]1)([O:65][C:66]([CH3:69])([CH3:68])[CH3:67])=[O:64]

Participants

4

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 15543039HCID 15543039, compoundHCID 22618212HCID 22618212, compound

Product 1

HCID 18373183HCID 18373183, compound

Procedure

By methods substantially equivalent to those described in Example 1-C, N-(-Boc-6-indazolyl)-2-[(4-methoxybenzoyl)amino]benzamide (280 mg, 39%) was prepared from p-anisoyl chloride and 2-amino-N-(1-Boc-6-indazolyl)benzamide.

Sources & evidence

ORD record
ord-f501ce87a3bf48dc88ef80174dcd79db
Source dataset
uspto-grants-2002_04
Patent number
US06372759B1

Reaction notes

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