反应详情

To a stirring solution of 6-nitro-2-[4-t-butylphenyl]-4H-3,1-benzoxazin-4-one (1.5 g, 4.62 mmol) in toluene (25 mL) was added 6-aminoindazole (560 mg, 4.2 mmol) and the solution was heated to reflux. After about 24 h, the solution was cooled, filtered and the solid was washed with diethyl ether. The product was then chromatographed over silica gel, eluting with 25% ethyl acetate/hexanes. The product containing fractions were combined and concentrated in vacuo to give 810 mg (42%) of pale yellow solid.

1. temperaturethe solution was heated to reflux
2. temperaturethe solution was cooled
3. filtrationfiltered
4. washthe solid was washed with diethyl ether
5. customThe product was then chromatographed over silica gel
6. washeluting with 25% ethyl acetate/hexanes
7. additionThe product containing fractions
8. concentrationconcentrated in vacuo