HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 3-Chloro-1H-indole-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 1H-indole-6-carboxylic acid | HCID 595230 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Chloro-1H-indole-6-carboxylic acid | HCID 15543042 | 80% |
Reaction Steps
To a solution of indole-6-carboxylic acid (2.45 g, 15.2 mmol) in dichloromethane (100 mL) and DMF (10 mL) was added N-chlorosuccinimide (2 g, 15.2 mmol). After 3 h, the solvent was removed in vacuo and the residue was suspended in dichloromethane, sonicated and filtered to give 2.38 g (80%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372759B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-63a6b74051dd46d4894513e8c19e6d49 |
| Source note | uspto-grants-2002_04 |