HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Diethyl-4-[4-(4-methylpiperazine-1-carbonyl)phenoxy]azetidin-2-one → HCID 22614062, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Diethyl-4-[4-(4-methylpiperazine-1-carbonyl)phenoxy]azetidin-2-one | HCID 9884584 | — |
| Reactant | HCID 22614049 | HCID 22614049 | — |
| Product | HCID 22614062 | HCID 22614062 | — |
Reaction Steps
According to the method of Shrenik et al (J. Med. Chem., 35, 3745-3754 (1992)), 4-[4-[[(4-methyl)piperazin-1-yl]carbonyl]phenoxy]-3,3-diethyl-2-azetidinone (160 mg, 0.463 mmol) and 4-(benzyloxycarbonyl)benzylisocyanate (261 mg, 0.98 mmol) gave, following purification by flash column chromatography (MeOH/EtOAc, 1:4), the title compound (171 mg, 60%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06375926B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-523ad01fc647438db2c92f13c4f984cc |
| Source note | uspto-grants-2002_04 |