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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 842437Generated: October 27, 2026

trans-Crotonyl chloride → (4R)-3-((E)-2-butenoyl)-4-(phenylmethyl)-2-oxazolidinone

https://huagongshe.com/reaction/842437

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttrans-Crotonyl chlorideHCID 643131—
Reactant(R)-4-Benzyl-2-oxazolidinoneHCID 2734969—
ReactantButyllithiumHCID 178418339—
Product(4R)-3-((E)-2-butenoyl)-4-(phenylmethyl)-2-oxazolidinoneHCID 11481966—

Reaction Steps

reacting (R)-4-(phenylmethyl)-2-oxazolidinone (5) with n-butyllithium and (E)-crotonyl chloride to produce (4R)-3-((E)-2-butenoyl)-4-(phenylmethyl)-2-oxazolidinone (6),

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06375943B1
Source datasetuspto-grants-2002_04
ORD IDord-6fb62c4d13f4483392b6d44fac772611
Source noteuspto-grants-2002_04