Hydrochloric Acid → Cryptophycin 55

Participants

Reaction Steps

To a solution of Cryptophycin 52 (6 mg, 0.009 mol, Example 22 or 22A) in 0.6 mL of 2:1 1,2-dimethoxymethane/water was added 2 μL of 12 N HCl. The solution was allowed to stir at room temperature for 20 h, neutralized with potassium carbonate, filtered through a 5μ filter, and evaporated. The acetonitrile-soluble material was purified by reverse-phase HPLC on C18 (250×10 mm column) using 4:1 MeOH/H2O to obtain 3.0 mg of Cryptophycin 55 (48%).

Provenance & Evidence