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HRID842495

反应详情

EQUATION

反应方程式

HRID 842495 的结构方程式

REACTANTS

反应物

1
结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID6665

(+)-Dihydrocholesterol

C27H48O

PRODUCTS

生成物

1
结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID10883573

3-Oxocholestane

C27H46O

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[O]=[Os](=[O])(=[O])=[O]
催化剂HCID30318

Osmium tetroxide

O4Os

结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

CONDITIONS

反应条件

温度
25 °C

PROCEDURE

实验过程

2.5 Millimole of 3β-cholestanol was dissolved in 50 ml of diethyl ether, and MCOsOx containing osmium tetroxide in an amount equivalent to 2.5 mmol was added thereto, followed by stirring at 25° C. for 30 hours to cause a reaction to take place. MCOsOx was removed from the reaction solution, and a crude keto compound was recovered from the filtrate and purified by silica gel column chromatography (eluent:benzene) to give 3-cholestanon at a yield of 90%.

WORKUP

后处理

  1. additionwas added
  2. customa reaction
  3. customMCOsOx was removed from the reaction solution
  4. customa crude keto compound was recovered from the filtrate
  5. custompurified by silica gel column chromatography (eluent:benzene)