Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-Methoxy-1H-indole | HCID 76659 | — |
| Reactant | O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine | HCID 11830845 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 11816030 | HCID 11816030 | — |
Reaction Steps
A mixture of 0.735 g 6-methoxyindole and 5 ml tetrahydrofuran (THF) is added to a suspension of 0.44 g of 60% sodium hydride in 10 ml THF at 0° C. After 15 minutes a mixture 1.07 g O-mesitylsulfonyl-hydroxylamine and 15 ml THF is added. Stirring at 0° C. is continued for 1.5 hours. The mixture is poured into ice cold water, extracted with ethyl acetate, and purified by flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06376426B1 |
|---|
| Source dataset | uspto-grants-2002_04 |
|---|
| ORD ID | ord-c17f8959d054479f94fb192877502069 |
|---|
| Source note | uspto-grants-2002_04 |
|---|
