Triethylamine → HCID 15426387, compound

Participants

Reaction Steps

0.53 g (1.53 mmol) of 2-chloro-3-cyclohexanyloxymethyl-4-methylsulfonylbenzoic acid was treated with 2 drops of N,N-dimethylformamide and 0.59 g (4.58 mmol) of oxalyl chloride in 23 ml of methylene chloride and the mixture was refluxed for 2.5 h. It was then stripped off on a rotary evaporator, the residue was taken up in 23 ml of methylene chloride and the mixture was treated at 0° C. with 0.19 g (1.68 mmol) of cyclohexanedione and 0.46 g (4.58 mmol) of triethylamine. It was stirred at room temperature for 4 h. It was then concentrated on a rotary evaporator and purified by chromatography (silica gel, ethyl acetate:hexane=1:1).

Provenance & Evidence