Acetic Anhydride → HCID 22614793, compound

Participants

Reaction Conditions

Reaction Steps

2-Amino-3-hydroxy-4-methoxybenzaldehyde (20.0 g, 0.12 mol) [M. Grossa, F. Wessely Monatsh. Chem. 1966, 97, 1384-1390] is dissolved at RT in a mixture of pyridine (250 ml) and acetic anhydride (250 ml). The solution is warmed to 60° C. and stirred for 1.5 h. The reaction solution is then poured onto a mixture of ice and half-concentrated aqueous NaCI solution (1:1), extracted with ethyl acetate (5 times), dried over MgSO4, filtered off and concentrated in vacuo. The title compound is obtained as a slightly yellow solid (12.5 g) after silica gel chromatography [petroleum ether/ethyl acetate (7:3)]. TLC, silica gel (glass plates), petroleum ether/ethyl acetate (7:3), Rf=0.23.

Provenance & Evidence