HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-(2-Chloropyrid-5-ylmethyl)-3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-(chloromethyl)pyridine | HCID 155479 | — |
| Reactant | 3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine | HCID 136277959 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(2-Chloropyrid-5-ylmethyl)-3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazine | HCID 54383374 | — |
Reaction Steps
A mixture of 1.44 g of 3-methyl-4-nitroiminoperhydro-1,3,5-oxadiazine, 2.2 g of 2-chloro-5-chloromethylpyridine, 3.7 g of potassium carbonate and 20 ml of N,N-dime-thylformamide is heated for 4 hours at 50° and filtered, the filtrate is evaporated in vacuo on a rotary evaporator, and the residue is purified by chromatography [silica gel; dichloro-methane/methanol (95:5)]. This gives the tide compound which melts at 116 to 118°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06376487B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-a4a73ec6d4284379b68405a03bee4311 |
| Source note | uspto-grants-2002_04 |