Ethyl Acetate → HCID 22940401, compound

Participants

Reaction Steps

A solution of (+,−)-N-(cis-2-(3-Ethynylphenyl)-cyclopropyl)-N′-(5-chloropyrid-2-yl)-urea of Example 22(130 mg, 0.42 mmole), H2SO4 (10 drops), H2O (10 drops) and Hg(OAc)2 (100 mg) in acetic acid (4 mL) was stirred at room temperature for 30 min. The reaction mixture was then poured into an ethyl acetate and saturated K2CO3 solution. The organic layer was dried (MgSO4) and the solvent was evaporated to give a residue which was purified on silica gel using 1:1 acetone: and hexanes as the eluent providing 43 mg of the title compound.

Provenance & Evidence