Acetyl chloride → HCID 22614897, compound

HRID 842675Notes

Reaction equation

HRID 842675 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[C:15]([Cl:16])=[C:14]([Cl:17])[CH:13]=[C:12]2[C:7]=1[N:8]=[C:9]([O:20][CH3:21])[C:10]([O:18][CH3:19])=[N:11]2>C1(C)C=CC=CC=1>[C:1]([NH:5][C:6]1[C:15]([Cl:16])=[C:14]([Cl:17])[CH:13]=[C:12]2[C:7]=1[N:8]=[C:9]([O:20][CH3:21])[C:10]([O:18][CH3:19])=[N:11]2)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 106066205-Amino-6,7-dichloro-2,3-dimethoxyquinoxaline

Product 1

HCID 22614897HCID 22614897, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Acetyl chloride (5.71 mL, 6.30 g, 80.3 mmol) was added to a vigorously stirred suspension of 5-amino-6,7-dichloro-2,3-dimethoxyquinoxaline (Preparation 26, 20.49 g, 64.8 mmol) in toluene (500 mL) and the resulting mixture was heated under reflux for 2 hours. After being cooled, the product was collected by filtration, washed with toluene and dried by suction for 15 hours to yield 5-acetamido-6,7-dichloro-2,3-dimethoxyquinoxaline (20.49 g, 89%) as a beige solid.

Workup

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 2 hours
  3. temperatureAfter being cooled
  4. filtrationthe product was collected by filtration
  5. washwashed with toluene
  6. customdried by suction for 15 hours

Sources & evidence

ORD record
ord-a88dc750c59b4e55893ccef3b647d69a
Source dataset
uspto-grants-2002_04
Patent number
US06376490B1

Reaction notes

Loading…