HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 842707Generated: October 25, 2026
Triethylamine → 3-amino-1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile
https://huagongshe.com/reaction/842707
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-Chloropyridine-3,5-dicarbonitrile | HCID 10986579 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-amino-1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile | HCID 178510334 | — |
Reaction Steps
Hydrazine hydrate (55%, 125 μL, 2.20 mmol) was added to a stirred suspension of 2-chloro-3,5-dicyanopyridine (240 mg, 1.47 mmol) and triethylamine (205 μL, 1.47 mmol) in ethanol (3 mL) and the resulting red mixture was heated to 60° C. After 16 h the mixture was cooled and filtered to give the title compound:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06376499B1 |
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| Source dataset | uspto-grants-2002_04 |
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| ORD ID | ord-7bac2a1c9f9e468fa8fa8cecea7a7103 |
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| Source note | uspto-grants-2002_04 |
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