Dimethylformamide → HCID 15886851, compound

Participants

Reaction Steps

70 mg (0.47 mmol) of 2-methyladenine was dissolved in a mixed solvent composed of DMF (15 ml) and water (5 ml). To this solution, 0.26 g (1.88 mmol) of potassium carbonate and 0.5 ml (about 2 mmol) of benzyl bromide were added and stirred at room temperature for 16 hr. After the solvent was removed by vacuum distillation, the residue was extracted with chloroform, dried over anhydrous magnesium sulfate and then concentrated. The resultant residue was purified by column chromatography (eluent:dichloromethane:methanol=50:1-30:1) to thereby obtain 0.12 g of 9-benzyl-2-methyladenine.

Provenance & Evidence