HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → (2-(1-(4-Cyanophenyl)piperidin-4-ylamino)ethyl)carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | N-BOC-ethylenediamine | HCID 187201 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 4-(4-Oxopiperidin-1-yl)benzonitrile | HCID 11019887 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2-(1-(4-Cyanophenyl)piperidin-4-ylamino)ethyl)carbamic acid tert-butyl ester | HCID 54428198 | — |
Reaction Steps
A solution of 35 (415 mg, 2.07 mmol), 1 (343 mg, 2.14 mmol), and acetic acid (629 mg, 10.48 mmol) in methanol (10 mL) was treated with sodium cyanoborohydride (140 mg, 2.23 mmol) at room temperature. The resulting mixture was stirred at room temperature (3 h). The solvent was removed in vacuo. PCTLC (SiO2, 4 mm, 10% EtOH-90% CHCl3) afforded the title compound (36).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06376503B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-381f7ee5cfdc425894689bb1db906fbf |
| Source note | uspto-grants-2002_04 |