HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic acid, 2-fluoro-, methyl ester → N-(2-Carbomethoxyphenyl)-4-piperidone propylene ketal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic acid, 2-fluoro-, methyl ester | HCID 67854 | — |
| Reactant | 4-Piperidone propylene ketal | HCID 12954117 | — |
| Product | N-(2-Carbomethoxyphenyl)-4-piperidone propylene ketal | HCID 57112551 | — |
Reaction Steps
A mixture of methyl 2-fluorobenzoate (16.0 g, 103.8 mmol) and 4-piperidone propylene ketal (9.8 g, 62.3 mmol) was stirred at room temperature (8 d). Flash chromatography on silica gel (10% MeOH-90% CHCl3) afforded the title compound (44).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06376503B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-28c81e13f9c34256a09e5abc018c2da1 |
| Source note | uspto-grants-2002_04 |