HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 14774141, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Cyanophenol | HCID 13394 | — |
| Reactant | 2-(3-Chloromethylphenoxy)methylquinoline | HCID 14501706 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14774141 | HCID 14774141 | — |
Reaction Steps
A solution of 0.65 g (5.4 mmol) 3-hydroxybenzonitrile, 1.5 g (5.3 mmol) of 3-(2-quinolinylmethyloxy)benzyl chloride, and 0.75 g (5.4 mmol) of potassium carbonate in 15 ml of DMF is heated at 60° C. overnight. The reaction mixture is poured into water. The precipitated product is collected on a filter and purified by dry column chromatography to give 3-[3-(2-quinolinylmethyloxy)benzyloxy]benzonitrile. (MP 86-87° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06376512B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-f19acc351315497fb499e34ca0a6cf23 |
| Source note | uspto-grants-2002_04 |