Ethylene Glycol → HCID 10777744, compound

Participants

Reaction Steps

To prepare compound 79u, a transesterification reaction shown schematically in FIG. 10 was used. Ethyl benzoylacetate (1.92 g, 10 mmol) and ethylene glycol (0.621 g, 10 mmol) in toluene (10 mL) were heated with stirring for 24 h. The solvent was removed, and the residue was chromatographed (silica 60, petroleum ether-ethyl acetate (3:1)) to give 0.946 g of the desired product, yield: 45%. The 1HNMR data are set forth below.

Provenance & Evidence