反应详情

N-(4-chloro-5-methyl-3-isoxazolyl)benzenesulfonamide was prepared from 3-amino-4-chloro-5-methylisoxazole and benzenesulfonyl chloride as described in Example 26b in 40% yield. The crude product was purified by column chromatography with 10-100% ethyl acetate/hexanes as eluent. A crystalline solid was obtained after recrystallization from ethyl acetate/hexanes, m.p. 139-141° C. 3-Amino-4-chloro-5-methylisoxazole (25% recovery) and N-(benzenesulfonyl)-N-(4-chloro-5-methyl-3-isoxazolyl)benzenesulfonamide (7% yield) were also obtained as less polar products.

1. customThe crude product was purified by column chromatography with 10-100% ethyl acetate/hexanes as eluent
2. customA crystalline solid was obtained
3. customafter recrystallization from ethyl acetate/hexanes, m.p. 139-141° C