4-Iodobenzenesulfonyl chloride → HCID 18617320, compound

HRID 842894Notes

Reaction equation

HRID 842894 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[I:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1>>[I:9][C:10]1[CH:15]=[CH:14][C:13]([S:16]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:18])=[O:17])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 73994-Iodobenzenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617320HCID 18617320, compoundYield 65%

Procedure

4-Iodo-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 4-iodobenzenesulfonyl chloride according to the procedures described in Example 25b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a yellow powder, m.p. 166-173° C., yield 65%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a yellow powder, m.p. 166-173° C., yield 65%

Sources & evidence

ORD record
ord-be8588049f5046bda09cd601f1d82511
Source dataset
uspto-grants-2002_04
Patent number
US06376523B1

Reaction notes

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