Benzenesulfonyl chloride → HCID 18617295, compound

HRID 842897Notes

Reaction equation

HRID 842897 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH2:7][CH3:8])[C:3]=1[Br:9].[C:10]1([S:16](Cl)(=[O:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[Br:9][C:3]1[C:4]([CH2:7][CH3:8])=[N:5][O:6][C:2]=1[NH:1][S:16]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 18617330HCID 18617330, compound

Product 1

HCID 18617295HCID 18617295, compoundYield 70%

Procedure

N-(4-Bromo-3-ethyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-ethylisoxazole and benzenesulfonyl chloride according to the procedures described in Example 25b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give off-white crystals, m.p. 90-93° C., yield 70%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give off-white crystals, m.p. 90-93° C., yield 70%

Sources & evidence

ORD record
ord-7aa8735e5aa14cb6a3644a74e8fc7caf
Source dataset
uspto-grants-2002_04
Patent number
US06376523B1

Reaction notes

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