Benzenesulfonyl chloride, 2,5-dimethyl- → 2,5-Dimethyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide

HRID 842899Notes

Reaction equation

HRID 842899 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[S:17](Cl)(=[O:19])=[O:18]>>[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[S:17]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:18])=[O:19]

Participants

3

Reactant 2

HCID 87910Benzenesulfonyl chloride, 2,5-dimethyl-HCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 186173772,5-Dimethyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamideYield 81%

Procedure

2,5-Dimethyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2,5-dimethylbenzenesulfonyl chloride according to the procedures described in Example 25b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give off-white crystals, m.p. 102-104° C., yield 81%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give off-white crystals, m.p. 102-104° C., yield 81%

Sources & evidence

ORD record
ord-c2d6a6dddd4743eb8005046d5daa4f26
Source dataset
uspto-grants-2002_04
Patent number
US06376523B1

Reaction notes

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